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In one meta-analysis of RCTs, metformin worked about three times as well when starting a new antipsychotic in first-episode psychosis (about a 13-pound difference from placebo) compared with its use after chronic antipsychotic treatment (about a 4-pound difference from placebo) (De Silva VA et al, BMC Psychiatry 2016;16(1):341)

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Patients with severe gastrointestinal disease , including gastroparesis, may not tolerate these medicines well due to their effect on gastric emptying

We will make payment, according to the statute, retroactively effective to the date that we determine that a product meets the criteria, with the earliest effective payment date being January 1, 2026